Wednesday, March 20, 2024

Live High Train Low and High - The Highest Technological Science behind the results


 

Internal View of Athletic Chamber supplied by QRA INTERNATIONAL  

Recently, our national sprinter Ms. Shanti Pereira has made the front pages of the news by coming in 2nd in the women's 100 m sprint and attaining the gold medal in the recently concluded Asian Games (2023 edition) in Hangzhou China.

Kudos to her and her team of coaches, sports scientists, nutritionists and officials for reaching the pinnacle of her sport and has made her the current darling of Singapore sportsmen and women. The team behind her success is instrumental in ensuring that her performance is approaching world standard. There is also a whole depth of scientific work and sports preparation  for many months and even years to get her performance to world class level and as a result slash her 100 m and 200 m times by so much. All legal and employing the highest levels of science and technology, coaching techniques etc - it is worth it.In my humble opinion.    

Two particular pieces of equipment which I wish to highlight ; the Singapore Sports Institute offers hypoxic sleep rooms with O2 levels of 3000 m or 18.6% O2 per cubic metre of air. Normal sea levels have 20.9 or 20.8% of O2 per cubic metre of air. They also have an athletic chamber of approximately 70m3 size (which my company supplied in 2016) whereby the athletes can train from the various temperature and humidity ranges :

The Technology 

Temp : 0 to 50 C

Hum  : 20 - 95 % rH

O2    : Sealevel or 0 m (20.9% O2) to 5000 m (16.5%) 

Additionally there are special components called : CO2 scrubbers which filter out (scrub) the CO2 from the air inside the chamber.

 

Fun Fact

People who are trapped in sealed enclosed spaces for long durations (freezer cold rooms for example)  die or faint from CO2 poisoning rather than from a lack of oxygen. The build up of CO2 caused by our breathing will rise to 8000 ppm and that is where faint headedness, dizziness, nausea sets in. If the environment is not rectified in time, by either 

1.  Releasing or scrubbing the CO2 away (by filters) 

2. Opening up the room and allowing the mixing of fresh air with O2 in and CO2 out

then the worse will happen ; disorientation, fainting and possibly death.

The Theory - General

Scientific studies have shown that elite athletes with well conditioned bodies (I highlight the words) can benefit from high altitude training. In the old days, many athletes went up to the mountains where the air was 'thin' and O2 levels were far lower than at sea level.

Live High (LH) 

This is where people who live high up the mountains, and endure low O2 levels for long stretches of time, for example, the Sherpas in the Himalayas. They have exceptionally well conditioned bodies. The reason ? Their haemaglobin levels in their blood are up to 50% more than ordinary people living at sea level height.

Train Low (TL) and Train High (TH)  

Training Low means to train at sea level.Training High is to train at altitude.

The Theory - Specific 

Our bodies have both aorta and veins, and smaller tubes called capillaries.In each cm3 of blood vessel tube, for example have (say) 10 haemoglobin molecules or small buckets whose sole function is to carry Oxygen molecules from the main O2 supplier (lungs) to the various parts of the body.

With the proper use of oxygen, the body breaks it down and burns in for produce energy for all manner of daily bodily movement from breathing, walking, running, everything.

So at sea level, if for 1 cm3 of blood there are 10 buckets of haemoglobin to carry 10 air molecules worth 1 oxygen content in size, so the effect is 100 HO of energy potential - for example. (not scientific). So if he runs at sea level, at a certain speed which he is used to, he can use up to 100 HO of energy potential, and this is limited by the number of haemoglobin buckets in his per cm3 of blood.

In high level (3000 m - which is base camp Everest), the number of O2 molecules is far less say 10 molecules air but with 7 oxygen content per fixed volume of air. Then the person's energy capacity would be reduced to 10 x 7 or 70 HO. Thus, he would feel lethargic and not be able to run at the same speed.

Hence, your body's performance is limited by the O2 concentration in the air leading to anything from disorientation, altitude sickness, light headedness and slower work rate.  

To enhance his performance, the person would have to CONDITION his body by living in low O2 conditions for up to 2 weeks, so that :

1. The amount of haemoglobin grows in the blood vessels (it is amazing but true and backed by scientific research). It typically grows by 30 to 50% . So for 1 cm3 of blood, there can be up to 15 haemoglobin buckets in 1 cm3 of blood vessel - after conditioning in hypoxic rooms (rooms with low levels of Oxygen) for up to 2 weeks.

2. After 2 weeks, the athletes have (say) 15 buckets of haemoglobin and 15 molecules of air with 0.7 oxygen content, then the energy capacity is 15 x 0.7 or 105 HO. Over time and LH and TH, he can run at approximately the same speed but with less oxygen in the air.!

Magic ? No, the body is a tremendous adaptable machine !   

LHTLH or LHTL ? 

Science has shown that athletes with the program of Living High LH (3000) and Training Low TL (sea lavel) have the best results.

This means, that after 2 weeks of altitude training - either by living in the mountain at 3000 m height, and then going to train on the track in the sea level (0 metre), what happens ?

What happens ?

The height conditioned body  now has 15 haemoglobin buckets and at sea level (0 meters), there are 15 molecules with 1 oxygen content.

The persons energy capacity increases to 150 HO  or 15 x 10 HO ! 

He (in theory) can run by up to 50% faster than his original speed ! 

The effect is temporary as the haemoglobin level reverts back to 10 if the athlete stays at sea level - but the effect can last up till 2 weeks after return to sea level.

TL or TH ? 

Science has also shown that there are tangible benefits to train at both low and high levels of Oxygen. 

So here it is, the technology explained in layman terms 

Hence with the right team, technology, discipline and dedication, success for all our national athletes is a reality ! 


                                    The Completed Chamber Front View

Interested ? Gym Owners, Recreational, serious and elite athletes please contact :

QRA INTERNATIONAL PTE LTD.

Subject : 1.  Athletic Chamber 

                2. Walk - In Chamber for Humans

               3.  Gym Pod 

Email :    1. qrasales@qra.com.sg

                2. mark@qra.com.sg

Price Range : from S$ 100, 000  (US$ 75, 000)  upwards



 




200,000 Views Wow ! Many Thanks !

 



I asked for 200,000 Views by March 2024 and we achieved it today 20 March 2024 


Dear readers and followers of my Blog.

Give yourselves a pat on the back ! 200,000 views. Wow ! Easily 20,000 views per month from the start of the year.

I am grateful for the eyeballs and will endeavour to keep this blog as informative, insightful and entertaining while factually correct (to the best of my knowledge).

Carpe Diem !  Carpe Nocte !

Testing of Sterile Barrier Systems for Biomedical Devices - 2024 Version Revised and Updated.

Many Health Authorities worldwide recognise the critical nature of a Sterile Barrier System.

What exactly is a Sterile Barrier System (SBS) ?



         Tyvek Seal and Polyurethane Packaging form the Sterile Barrier System in this Picture 

This is the external barrier (some examples can be Tyvek material or Polyurethane seal) which separates the internal components, powders, medicines etc from the elements. Hence it is crucial that the sterile barrier is never compromised.

A key function of a sterile barrier system is to maintain the safety of a terminally sterilised medical device until its point of use - typically in a healthcare setting.

QRA International network of Laboratories can evaluate the sterile integrity of your final packaging design through a series of seal integrity  and seal strength testing outlined in ISO 11607 - Packaging for Terminally Sterilised Medical Devices. 

Seal integrity testing identifies any leaks around the seal area of your packaging system.Seal integrity testing identifies any leaks around the seal area of your packaging system. Seal integrity testing is followed by seal strength testing to evaluate the mechanical strength of your packaging system and the force needed to separate and open the seal. A high numerical force value could indicate challenges in opening your packaging system by hand, and a low numerical force value could indicate poor bonding of materials.

Choose QRA International Medical Device Testing to help you to :

a) Validate your final packaging system 

b) Monitor proper device performance during the manufacturing process.

c) Establish material compatability and proper bonding to maintain the sterile environment throughout the shelf life of your product.

d) Ensure the seal of your packaging system does not change due to environmental stressors such as distribution and shelf life.

Tests Available by QRA and its partners :

Accelerated Aging Tests

1. Accelerated Aging Tests (ASTM F 1980 - 21 and ISO 11607)

2. Shelf Life Test 

Seal Integrity Tests

1. Visual Inspection (ASTM F1886)

2. Dye Penetration (ASTM F 1929  & F 3039)

3. Bubble Emission (ASTM F 2096)

Seal Strength Tests 

1. Peel / Seal Strength Test (ASTM F 88, EN 868 - 5 Annex D).


Interested ? Contact the friendly QRA International Sales Specialists at 

email : mark@qra.com.sg

            qrasales@qra.com.sg 


Or visit our website at www.qra.com.sg for more information 


We are here to serve the International Biomedical Community 



Sunday, March 17, 2024

Stuck Marmite Bottle Top - Why heat helps ?

Ever had problems with Bottle Tops are they are kept in the larder or fridge for a long time ?  I can hear a chorus of "yes !" from my army of readers (easily 1000 per day !). You huff and you puff, use some cloth and try with all your might. 

Eventually you get it open. Many times, it is stuck and you are mightily flustered. Ever wondered why ?

My experience in the field of environmental testing sales, manufacturing servicing of such test chambers for the last 25 years has the solution. 

Coefficients of thermal expansion. Yes, every thing heats up (or expands) when it is heated, however slowly. There are complex thermal expansion formulae, which is not necessary for this post. However each type of material heats up and expands according to the heat added to it.

You have heard how hot air rises ? Well air also expands as it is a gas but it is boxed in the receptacle (room, balloon or container) and it cant be seen. 

QRA has for years been selling thermal shock test chambers (see picture) whose purpose is to see if the samples do 'break' over time or over thousands of heat / cold cycles called temperature cycles.


   

   2 Zone Thermal Shock Chamber with Hot Zone (over 70 C) and Cold Zone (-60 C and below)

So, coming back to the Marmite bottle. You have tried for 1 minute. WAIT, you place it out in the kitchen (during summer time I am assuming). It was in the refrigerator for say 1 week. 

Come back after 15 minutes. It would have heated up to near room temperature (say 20C)

The 2 materials which are in contact with the Cap are Glass and the Cap (Plastic / Polyethalyne). See Picture Drawing Below Stage 'A'. 


Marmite builds Strong Bones and Teeth 


The Theory Explained in the Picture Below 




As the bottle heats up, the 2 materials will expand at almost microscopic amounts. Magnified under a scope, the cap will expand down and stretch out while the bottle expand up. (See Stage 'B').  If both had the same coefficient of thermal expansion, the points touching would NOT change.

BUT since plastic expands MORE than Glass, hence the movement DOWN is MORE THAN the movement UP by the glass.

Hence gaps will formYou can then open the Bottle.

Voila ! Physics Explains this Everyday Frustrating Task and its Solution 

How to Heat Up the Bottle ?

Impatient people 

1.Put in a Microwave for 10 seconds or so (Not Recommended)

2.Immerse Fully Bottle in Hot Water

3.Use a Lit Match to Heat around the edge of the Bottle (we did that 40 to 50 years ago with  success). 

Everybody Else

Let it sit for 15 minutes and try again. 


HAVE A GREAT WEEKEND MY READERS ! 

 




Thursday, March 7, 2024

Accelerated Aging and Shelf Life Testing according to ASTM F 1980 - 21 and ISO 11607 - QRA INT'L the only Lab specialising in Asia.

Every medical device is required to be labeled with an expiration date that is supported by shelf-life data. Accelerated-aging tests are employed to generate this data for design-history files, technical dossiers, and 510 (k) submissions, while concurrently running real-time studies.

For many medical devices that are manufactured from metals and robust plastics, the evaluation time for a product’s shelf life can be significantly shortened by aging the materials at elevated temperatures (often as high as 55oC). Other products, such as biologic materials or products made of thermally sensitive materials, require a more thorough aging study design with environmental chambers relevant to more unique product requirements.



QRA Walk In Chamber 

With more than  3000 ft2  of environmental chamber space in 2 Labs, meeting ASTM, ISO, and ICH conditions, QRA International's network of laboratories has the capacity for accelerated aging and real-time shelf-life studies to meet your needs quickly, inexpensively and  with full test report submissions.

Our chambers are housed in secured areas, continuously monitored and integrated iand regularly calibrated in accordance to ISO 17025 International Safety Standards.

Website : www.qra.com.sg

Email     : mark@qra.com.sg 

                qrasales@qra.com.sg

QRA INTERNATIONAL PTE LTD. 

(TEST LAB FOR BIOMEDICAL AND PHARMACEUTICAL INDUSTRY)

Address  : 21 Toh Guan Road

                 # 04 - 02 Toh Guan Centre

                 Singapore 608609

Tel  : (65) 6795 1486 

Choose QRA INTERNATIONAL PTE LTD.  to help you : 

  • 1.Establish product shelf life under both accelerated and real-time conditions. 
  • 2.Meet regulatory requirements following ISO 11607-1, ASTM F1980, or any custom-  testing protocol needed to establish your product’s expiration date.
  • 3.Get comprehensive analysis through one provider, including package integrity, sterility, and product functionality testing such as mechanical, electrical, and physicochemical testing.
  • 4.Access study progress through our regular test report updates..
  • 5.Ensure easy monitoring of multiple long-term studies and a device’s overall protocol plan using a document control system.

  • 6.Utilize an International Shipping Specialist (DHL) to  ship products anywhere in the world, navigating permitting, importing and customs.

  • We have test customers from USA, Middle East, Australia and Asia 

  • 7. Support protocol writing and method development / validation.

Lets make this life a good one. Can I get 300,000 views by June ?


Recently, I had a revelation. But I have come to realise that to be remembered, I need to provide some value to the people around me. In addition, after a certain time,  you see many things with the clarity of accumulated experience and shared experiences of your family, friends, business associates and aquaintences.

I learn what I don't want to end up as

I understand my limitations

I understand my strengths

I realise that you can't please everybody so its better to prioritise who you must please first and foremost.

I realise that I am a leader and leaders need to serve first and foremost. 

I need to give my team the right direction and then if they go astray I need to bring them back to the correct path.

Priorities in Life ( Most important ranked 1) 

1.Health

2.Your Relationships with your Partner Spouse

3.Family Cohesion and Care (Filial Peity)

4.Money

5. Friends Situations. 

6. Business and Appearence

I believe I do not need to elaborate on each one as these should be self explainatory 

Some Mismatched Priorities

Different folk will place the items in different order, hence I will not explain the rationale for mine. 






Sunday, March 3, 2024

QRA's Lab running continuosly for Accelerated Aging Tests



QRA INTERNATIONAL PTE LTD 

HQ : Singapore

Subsidiaries (2024) : Australia

(2024) Thailand.

We have 20 Test Chambers in 2 Labs ready to serve our clients worldwide 

Email : mark@qra.com.sg

Website : www.qra.com.sg

Tel : (65) 6795 1486 

QRA Vision Statement

  A Constant Reminder to myself and my readers of the reason why QRA is in existence.