Monday, February 12, 2024

Hypoxic Chambers 101 (Reproduced from SimpliFast website)


Hypoxic Chamber Supplied by QRA to Sport Singapore in 2016 

Consumer-friendly and professional hypoxic chambers are now a normal part of endurance development and team sport conditioning. Recently, the fitness industry has become a customer of hypoxic chambers, as the rapid adaptations that altitude simulators provide is commercially appealing.

In this buyer’s guide, we review the details of investing in altitude chambers and cover the necessary terminology, science, and practical considerations so coaches and high performance staff will have the necessary information to get started. The benefits are simple: improved aerobic capacity from specific hematological adaptations that improve athlete stamina. Most of the research supports what we can do with altitude tents and indoor hypoxic chambers, but the magnitude is still unknown when addressing their real-world impact on athlete careers versus short studies. The final word on how to use the technology will be up to the sport scientists and coaches, but for now the use of altitude tents has merit.

What Is a Hypoxic Chamber?



Athletic Chamber in Aspire Hospital Doha Qatar
Proudly Supplied by QRA International in 2017 


A hypoxic chamber is an area of any size that simulates altitude conditions, and applications range from specialized training rooms to bed tents that allow athletes to sleep with the physiological conditions found at higher elevations. Don’t confuse hypoxic chambers with hyperbaric chambers, or systems that increase the oxygen content of the local environment. Hypoxic conditions are researched to help intensify the adaptation process, but the effects relate highly to the entire training program and lifestyle of the athlete. While the systems are mainly for enhancing athlete performance, some treatments are for non-athlete use, such as wellness centers and rehabilitation clinics.

Don’t confuse hypoxic chambers with hyperbaric chambers.CLICK TO TWEET

There are three categories of equipment currently available: small sleep space areas, direct breathing devices, and training room solutions. All three systems can help an array of athletes, ranging from elite endurance athletes to senior populations. The popularity of hypoxic chambers is growing in Europe, and they are now available in the U.S. for fitness and performance demands. Hypoxic chambers are not like gas analyzers or commercial restricted breathing masks, as oxygen utilization and restricted breathing are not true hypoxic technologies.

Single user breathing devices are systems that replicate altitude by directly connecting the individual athlete to an inhalation stimulus similar to elevation. The athlete can sleep or train with the system, and the surrounding area maintains normal conditions. Like a CPAP machine, but clearly designed to stress the athlete incrementally instead of restore breathing, the technology is safe and effective.

Sleeping areas are commercially available, and due to their size and the user experience, they are popular with recreational athletes and team sports. Because of the invasiveness to sleep, specifically the social barriers, the market isn’t close to saturation in the space. Hypoxic sleeping devices resemble tents, and are often referred to as altitude tents to convey the concept of the appearance and function of the solution. Some systems are reportedly uncomfortable to sleep in because the temperature can be slightly warmer than ideal conditions, so decreasing the bedroom’s temperature is the common adjustment.

Training zones require specialized construction of the room to ensure the space is literally airtight. Sizes range from small single training areas that athletes can cycle in individually all the way to team-sized environments. In addition to an airtight area with unique entryways, altitude generators are required to alter the internal environment and replicate elevation. Training areas with hypoxic technology are very popular with athletes in team sport. While most in team sports are not interested in sleeping high artificially, all athletes use the training chambers.

How Does a Hypoxic Chamber Work?

Inside the Sport SG Chamber 

Control 
Temperature : 0 to 50 C
Humidity : 20 - 95%
Altitude : 0 - 5000 m
CO2 Control : 400 ppm for 2 hours with 4 athletes

A hypoxic chamber is an artificial environment solution that senses the ambient conditions of the local area and has the ability to distort the oxygen profile, thus simulating altitude. The equipment makes calculations that increase or decrease the simulation with a high level of accuracy. In summary, a hypoxic chamber fools the body into believing the athlete is at elevation.

Similar to an air compressor, the generators are about the size of a washer and dryer, and sometimes larger than full-size refrigerators depending on the amount of air treated. Due to the electrical energy required to modify large spaces, the temperature of the generators used to be an issue in confined spaces. It’s important that coaches and others involved recognize that air flow is purposely restricted in hypoxic chambers, so air conditioning and air filtering is sometimes a challenge.

In summary, a hypoxic chamber fools the body into believing the athlete is at elevation.CLICK TO TWEET

Small systems use similar technology, but tents and other small-space solutions are not as powerful because they use fewer cubic liters than full room chambers for teams and large groups. Mask solutions are similar, meaning they utilize the same engineering but on a far smaller scale. Partial pressure of tents and other systems is not modified by technology, therefore the main difference with air at sea level is its nitrogen and oxygen ratio.

What Does the Science Say About Hypoxic Training?

The physiology of simulated altitude is important because athletes who artificially live high but train at sea level improve their tolerance and adaptations, but do not fully prepare for the rigors of altitude. Conversely, those who train in hypoxic conditions with short intervals also limit their exposure to altitude, as it requires a combination of living and training to fully capture the absolute benefits of elevation to the body. Team training is also usually limited to cross-training or non-specific conditioning, so the transfer and replication of game conditions are not interchangeable. The amount of general training that transfers at sea level is conflicting, but added conditioning at altitude or simulated altitude does have a stronger influence on adaptations specific to aerobic performance.

Nearly all of the improvements in aerobic capacity will come from the mitochondrial, hematological, and cardiopulmonary adaptations. Concurrent training methods that incorporate both power and endurance should be enough to preserve an athlete’s ability to produce power, and extend the aerobic capacity to repeat it and conserve those capabilities. The rate of decay—meaning how quickly the adaptations occur—is highly dependent on a myriad of factors, mainly training, genetics, diet, and recovery.

Genetic factors are a real component in the success of athletes, as some athletes don’t seem equipped to harness the simulated altitude. Conversely, some athletes are high responders due to their genetic profile. Other circumstances make hypoxic training invaluable, such as immobile athletes after surgery or illness. Based on the research, it’s not clear who makes an ideal candidate for altitude training, so determining the athletes who are best fit to use altitude simulation with hypoxic rooms and tents is a difficult process.

Standard Features and User Experience



Sports SG Chamber can fit in :
a) 4 Olympic Sized Treadmills
b) 2 Cycling Machines

Most, if not all, of the systems available have a limited warranty (up to 24 months) for conventional use. Some chamber systems have maintenance packages or agreements that minimize expenses, and nearly all of them have been tested for safety and effectiveness. Many of the features are universal, meaning the market is not dramatically different, just similar enough that comparisons are not necessary outside of basic information on offerings and prices.

We don’t intend to oversimplify, but hypoxic chambers are very similar to air conditioning units, as they display simple environmental data and provide a solution to change the conditions accordingly. As for the private or individual products, each system has ergonomics and design differences that are small but reliable for purchasing, such as workflow and simplicity. Unlike equipment in our other buyer’s guides, individual key features are not the primary selling point.

What Options Exist with Hypoxic Technology (Rooms, Tents, Face Masks)?

There are a handful of players in the space and most of the companies support all of the markets, ranging from serious weekend warrior to professional institutions. We list the five companies that lead the industry for hypoxic chambers, tents, and individual systems. While the choice of options is narrow, each company’s experience should give you confidence that they’ll still be around in a few years, despite the fact that the sports technology market can be so volatile.

Worldwide Suppliers 

1. Hypoxico (USA)

2. Sporting Edge (UK)

3. QRA International (Singapore)

4. Higher Peak (UK).


QRA International Pte Ltd

www.qra.com.sg

Email :qrasales@qra.com.sg

           mark@qra.com.sh

Tel     : (65) 6795 1486

21 Toh Guan Road East

#04 - 02 Toh Guan Centre

Singapore 608609

Supplying world class Hyopoxic Environmental Chambers to the World 









Sunday, January 28, 2024

Regulatory Overview of Health Supplements - Singapore

 This is an article taken from the web, from the HSA website, so I do not own any of the content of this. It is only for public dissemination and information. Please read up further if you want the whole  article for better context and understanding.

What is a Health Supplement ?

A health supplement is a product which is used to supplement a diet and to support or maintain,enhance and improve the healthy functions of the human body. It cannot be an injectable or a preparation that needs to be sterile, such as injections or eyedrops. It cannot be an item of a meal or diet.

A health supplement must also contain one or more, or a combination9 of the following ingredients :

a. Vitamins, minerals,amino acids, fatty acids, enzymes,probiotics and other bioactive substances

b. Substances derived from natural sources, including animal,mineral and botanical materials in the forms of extract,isolates, concentrates and

c.Synthetic sources of ingredients mentioned in (a) and (b).

A health supplement must be administered in small unit doses in dosage forms such as the following :

1. capsules

2.softgels

3.tablets

4.liquids

5.syrups

Products used on animals as well as products presented in the form of food and beverages,such as biscuits,coffee and juice are not supplements.

Controls of Health Supplements

Health supplements are not subject to approvals and licensing by HSA for their importation, manufacture and sales. HSA prohibits the addition of medicinal ingredients such as steroids in health supplements. HSA also sets strict limits on toxic heavy metals in these products. Dealers have the obligation to ensure that their products are not harmful or unsafe and that they conform with the following guidelines before supplying health supplements into Singapore.

Voluntary Notification .of Health Standards

Dealers may voluntarily notify HSA of their health supplements supplied in Singapore.Companies MUST provide HSA with relevant documents to demonstrate that their products meet the necessary safety and quality standards 

+ Substances NOT allowed

+ Toxic Heavy Metal limits

+ Microbial limits

+  Vitamin and mineral limits

(Please refer to HSA website under the heading "Regulatory Overview of Health Supplements - Singapore for the details.)



Our range of over 20 test chambers are running 24 / 7 for shelf life accelerated aging tests for international clients in over 3 continents 

Speak to your friendly sales representative for QRA International NOW !



Quality Standards

Your Product Needs to achieve acceptable standards of quality in terms of 

>Product Stability and Shelf Life -   (QRA International can definately help your business here !)

> Storage Conditions and Distribution Practice (QRA International can definately help your business here !)

Manufacturing, packaging and assembly conditions. 

QRA International can assist your company in meeting the Quality Standards to meet the stringent requirements for sale into Singapore.

Speak with the experts, call QRA International today !

Tel : (65) 6795 1486

Or email : 1. qrasales@qra.com.sg

                 2. mark@qra.cm.sg

Website : www.qra.com.sg

We afe here to assist you in meeting your Quality Goals locally and internationally !



Sunday, January 14, 2024

Shelf Life and Accelerated Aging - Biomedical and Pharmaceutical Products

Every medical device is required by law to be labelled with an expiration date. The key question to every consumer is this. What exactly is an "expiration date" ? Is the performance of the device guaranteed  to be the same up until that magical date and then falls off dramatically after that ?

How do the manufacturers 'know; that the devices or products can really last that long ?

Thats where the decades long studies and the international standards have been put forth out in the market by top standards bodies such as ASTM (ASTM F 1980 - 21) and ISO (ISO 11607-1) for the US and European markets - the 2 largest consumer markets in the world for such products.

Testing your products and accelerating the aging of your products lends you credibility when you have the product rubber stamped on the box.

The test strategy for any biomedical or pharmaceutical company wanting to attain permission from  the FDA or the European market is to perform these aging tests by either : 

a) procuring accelerated aging chambers 

b) outsourcing these aging tests 

and conducting these tests.

For many biomedical devices that are manufactured from metals and robust plastics, the evaluation time for a product's shelf life  can be significantly shortened by aging the materials at elevated temperatures (as high as 70 C can be set).

Other products, such as biologic materials or products made of thermally sensitive materials, require a more thorough aging study design with environmental chambers relevant to more unique product requirements. 

Choose QRA International - the only Lab in Asia DEDICATED to 

ASTM F 1980 - 21   (for application for FDA approval to sell in USA market)

and ISO 11607 - 1   (for application to sell in the EU market) 

1. Establish product shelf life under both accelerated and real time conditions.QRA offers both test conditions at our 2 State of the Art Laboratories in Singapore and we are exploring setting up new Labs in Australia and USA. 

      An example : 

     Accelerated Aging in Chamber                              Real Life Test in Chamber

    55 C 50%    -  4.5 months         Equivalent to :          25 C 50% - 36 months (3 years)

2. Meet regulatory requirements following the ISO 11607 - 1 and ASTM F 1980 or any custom testing protocol needed to establish your products expiration date.

3. Start, Monthly, Weekly and End Test Reports backed by ISO 9001 : 15 traceability sent to you by email.

4. Additionally, QRA International provides comprehensive post tests, such as Peel and Bubble Tests to determine Sterile Barrier Hermiticity and package integrity

QRA also sells these shelf life testing chambers under our QRA brand. 

For more information, contact :

Tel :(65) 6795 1486

www.qra.com.sg

Email : 1. qrasales@qra.com.sg

            2. mark@qra.com.sg

There is never a better time to improve your products branding. Talk to the experts today. 



                            Laboratory 1 at Toh Guan Centre, 04 -2 Toh Guan Road East

                                                                   Singapore 608609 









  

Saturday, January 13, 2024

Testing for Sterile Barrier Systems or SBS

Many Health Authorities worldwide recognise the critical nature of a Sterile Barrier System.

What exactly is a Sterile Barrier System (SBS) ?



         Tyvek Seal and Polyurethane Packaging form the Sterile Barrier System in this Picture 

This is the external barrier (some examples can be Tyvek material or Polyurethane seal) which separates the internal components, powders, medicines etc from the elements. Hence it is crucial that the sterile barrier is never compromised.

A key function of a sterile barrier system is to maintain the safety of a terminally sterilised medical device until its point of use - typically in a healthcare setting.

QRA International network of Laboratories can evaluate the sterile integrity of your final packaging design through a series of seal integrity  and seal strength testing outlined in ISO 11607 - Packaging for Terminally Sterilised Medical Devices. 

 Seal integrity testing identifies any leaks around the seal area of your packaging system.Seal integrity testing identifies any leaks around the seal area of your packaging system. Seal integrity testing is followed by seal strength testing to evaluate the mechanical strength of your packaging system and the force needed to separate and open the seal. A high numerical force value could indicate challenges in opening your packaging system by hand, and a low numerical force value could indicate poor bonding of materials.

Choose QRA International Medical Device Testing to help you to :

a) Validate your final packaging system 

b) Monitor proper device performance during the manufacturing process.

c) Establish material compatability and proper bonding to maintain the sterile environment throughout the shelf life of your product.

d) Ensure the seal of your packaging system does not change due to environmental stressors such as distribution and shelf life.

Tests Available by QRA and its partners :

Seal Integrity Tests

1. Visual Inspection (ASTM F1886)

2. Dye Penetration (ASTM F 1929  & F 3039)

3. Bubble Emission (ASTM F 2096)

Seal Strength Tests 

1. Peel / Seal Strength Test (ASTM F 88, EN 868 - 5 Annex D).


Interested ? Contact the friendly QRA International Sales Specialists at 

email : mark@qra.com.sg

            qrasales@qra.com.sg 


Or visit our website at www.qra.com.sg for more information 




Friday, January 12, 2024

Leaders Eat Last ; Traits a Leader must Have

  I have been in business for over 20 years. That is a pretty long time, and the time tested takeaways I have gleaned from the "School of Life" is this :


     Find a Purpose

a) The world owes you nothing. So never expect anything except fresh air and sunshine. The rest, you need to find out for your self what is your purpose in life.

     Focus 

Once you set your goals. Review them every day or at least every week. Be brutally honest about how far you are in reaching your goals and FOCUS on it every day. If you are not anywhere near it, you had better do something.

    Thick Skin

Develop a thick skin. There will be many brickbats and naysayers when you strive to achieve your goals. Do not be disheartened for you only receive the ultimate satisfaction once you achieve them not the people who dish out the criticisms.

Take a good look at criticisms and see if you really need to change course or adjust your goal expectation.

Even if everyone is against you, you know you need to press on. That is why you are the leader. Leaders make painful  correct decisions. Not populist ones.

     Humility 

Be humble in your achievements. This will always put you in the right path upwards.

    Courage

Be courageous (not foolhardy) to push through even though everyone is bailing out. It is a test of your derring do and try not to throw good money after bad. 

Stand firm.Take charge if your life. Don't be the one when at the your wake, people come up to your dependents and mutter :  

"Oh he was a nice guy but he just never went anywhere with his life"


Carpe Diem !!! 





Wednesday, January 3, 2024

To Be a Strong and Confident Person do these 7 Things ; Concept from Mr. Steve Wohlenhaus CEO at Weatherology


People  by nature do things to sabotage their paths to success. We choose to believe in the rhetoric of limitation, 

"No it can't be done."

"Its too difficult"

"You could have taken the easy route"

"You could've done better only if you listened to me !"

Sounds familiar ? 

Life isn't fair, and we should not depend on Governments of the day, family, or blame ill health, bad weather or genes to determine why you are stuck in the rut.

Everybody in power will say, "lets level the playing field."

Sure, but I think it will be a long time before the trickle down effect affects you, unless you are very high up the political heirarchy or are in some high end MNC.

We need to transcend the politics, and transform our lives NOW.

We do not make excuses and marinate in the mediocrity of blame and outrage.

No, No. No.

External events (global crisis, goepolitical events, natural disasters) are never the answer for personal improvement.

We must make personal improvement a goal irregardless of how well the economy is doing.

"Real transformation requires real honesty. If you want to move forward, get real with yourself"

"Do not kid yourself into mediocrity" 

In my next post I will identify the 7 traits and steps and I will act on them.

You should too.



  

  

Monday, January 1, 2024

Mental Toughness - The Works in a Single Slide ; Phase 1 - Identify the 4 Cs.

 



This is something which I want to improve this 2024 and beyond. My mental toughness. 'No more Mr. Nice Guy' is the tagline for the song, but its not quite an accurate description of my planned persona for 2024.
 
Step Up, Face the Heat, and Stay Focussed all the way till I get the goal attained

C (1) - Control 

Emotional and Life Control  
Always tell myself, when shit happens, I always have options to resolve and even improve the situation.  Never never go to pieces by becoming irrational or emotional ; whats the point in that ? 

Do a Risk Reward Analysis before venturing into unchartered pathways in life. 
Is it worth it ?

Confidence in my Abilities and Interpersonal Confidence
I am a very confident person, by nature, and every setback while painful, will shake my confidence - but to a certain degree - and no more. 

Pick myself up from the floor ; do a self check as to why the event occurred and what my price to pay is. Learn never to make that same mistake again 

Do not depend on external influences, friends, family, medicines or even religion to help you.
It is the power of positive thinking that will always claw you back time and again. 

Press On. 

Committment to the Goal (s) 

Once I am committed on a goal, I jolly well put 110% of my mind, abilities and resources to attaining this and completing it. No more no less. 

My very good friend Suresh who is based in Australia, gave me the Gantt Chart flow for me to assimilate into my life, the goals and achievements I have set for myself. I think this is an excellent piece of advice. 

Set the goals at the right, the timeframe I need to set aside, the resources I will need, the effort and the improvment in terms of infrastructure, staffing, opportunity costs and all. The more detailed I am, the better Control I will get and the easier the goal is attained with clarity.

I am assessing which of the 4 I am strong or weak with and will work on the weak ones.

Goal Oriented - strong

Achievement Oriented - strong

Learning Oriented  - strong

Risk Oriented  - quite weak

I saw this lovely piece some years ago and I'd like to repeat it to myself.

If you set 0 targets, 100% you will hit it all the time. 

Challenges

Is my glass half full or half empty ? Its so easy to lay in bed and wait for the sun toi reach midday and do nothing, it is a recipe for disaster. Depression, anxiety and all the ill health awaits people who just await the inevitable.

We all face setbacks every year, some more than others. If you always moan and groan and say "why me ?" what does that do in any way to make your state of mind any better ?

It doesn't. 

There are literally billions of people struggling and in worse shape than me and you. Think about it ! 

So, treat each event which made you unhappy or stressed as a challenge. 

Challenges are meant to be overcome, and not to be overwhelmed so much so that you lose focus of your life's big picture or calling. 

Once you overcome it, you learn from it and it will be an event you will smile when you recall that period.

One of the toughest mental stressing times  for me was during my National Service days in the artillary. That was in  the year 1981 and we 15 souls were selected to undergo 12 weeks of sheer hell on earth (my opinion). We were lance corporals and we went into the course to attain our 2nd stripe for full corporal status. 

I was and am proud to say I made it. We underwent the 120 mm towed mortar training which only the toughest minded (not physically strongest() ones survived.

I graduated 11th out of 15 Non Commissioned Officers with great pride and humility. 

The artillary training was crazy, stressful and we were constantly on our toes to be thinking out of the box, following terse instructions with severe consequences if we failed.

Many of my fellow trainees went to hospital for surgery, internal bleeding, and total blackout due to sheer exhaustion. I was struggling many times, but still persevered mainly through grit, and emotional support from my family. 

Those were trying times, but we made it.

Mental stress and ability to handle the stress is one determining factor of true success in life. Bite the bitter medicine. Press On. Complain less. Do the Tough Work when called upon. 

Make Painful Decisions. 

Today, many of my fellow ex-trainees are very successful in life and I am proud to be associated with them as a fellow graduate from one 

We will all die someday. Some from disease, some from unfortunate accidents, some from old age and some through mental health issues.

So what ?  Make the most of each and every year to the best of my (your) abilities. 

For in the end, what matters is that I (and you) try to leave a big imprint on the people around us and that is what truly matters. 

So I will go into 2024 with this GRIT mentality.

Time is no longer my friend. 

Success only comes to those who seek and try ever so hard again and again to attain it. 





How to Prioritise Effectively 101

  This is a 120 % super effective way to prioritise your time each and every day as well as weekly, monthly and so on. Spend a good 15 minut...